Melatonin has been a popular sleep aid in the U.S. for decades. Between 2007 and 2012, usage of the supplement more than doubled in America1, and millions of people now keep it at their bedside for sleepless nights. Magnesium’s entrance to the sleep market has been more recent, but initial research shows that this essential mineral could be a helpful tool for getting the mind and body ready for bed.* Here are the main differences between how these two readily available sleep aids work. The isolated hormone has been studied as a sleep aid since the late-1980s, and research has confirmed2 that it can help people who need circadian rhythm support and reset, for example with jet lag and wonky work schedules (i.e., shift work). Whether regular vs. occasional melatonin supplementation is relevant depends on individual needs. It’s important to note that the supplement may help you fall asleep but doesn’t necessarily improve sleep quality or duration. When it comes to dosing melatonin and possible side effects, mbg’s director of scientific affairs Ashley Jordan Ferira, Ph.D., R.D.N. explains that, “a person’s melatonin dose should be determined in partnership with a trusted healthcare practitioner. Some people may experience headaches, grogginess, and sleepiness upon waking after taking melatonin—likely because the dose is too high for regular use (i.e., greater than 1 milligram), which can lead to desensitization of melatonin receptors and be counterproductive.” Ferira goes on to divulge this pro-tip: “it’s important to note that most melatonin is synthetic, while a minority of products are plant-sourced and harder to find.” Magnesium glycinate (aka magnesium bisglycinate) is a high-quality chelate form that’s bioavailable, gentle, and helpful promoting sleep.* It’s a combination of magnesium and the amino acid glycine, which also independently enhances sleep quality and neurological function3. Ferira shares that, “when we comb the clinical research on magnesium supplements and sleep4, we see that this mineral can help improve various sleep measures, including research outcomes like ‘sleep efficiency, sleep time, sleep onset latency, and early morning awakening.’”* In other words, magnesium can help you get to sleep and achieve longer, deeper sleep.* One of magnesium’s sleep-promoting mechanisms is that it reduces cortisol and increases melatonin levels in the body.* Its relaxing properties likely also have to do with the fact that it activates GABA receptors in the brain, which have a calming and balancing effect on the nervous system.* Be sure to turn off the lights and get off your electronics at that time to give it the best chance of kicking in. If you have a job that requires you to be up at night and asleep during the day, melatonin can also help get your body used to winding down when it’s still light outside. Since there isn’t much research into the long-term effects of taking high-dose melatonin every night, you’ll want to take it only as necessary. The recommended dose depends on personalized needs, but for acute doses for resetting your circadian rhythm, research points to the 0.5 mg to 5 mg5. But Ferira explains that, “a more modest dose of melatonin in the 0.3 to 0.5 mg range, which mimics physiological melatonin levels, is prudent if you’re taking this supplement for daily circadian rhythm support over the long term.” “Magnesium helps to calm down the central nervous system, which helps to prepare the brain to turn off and also to keep it functioning at a calmer level throughout the night.”* Since magnesium is a mineral and not a hormone, there’s less concern over taking it every day, though you should always talk to your doctor before introducing a new supplement into your routine. This ability to promote a longer-lasting state of relaxation is why mindbodygreen chose magnesium as the workhorse of our sleep supplement, sleep support+. The formulation includes 120 mg of magnesium bisglycinate (a highly absorbable form of the mineral) as well as other sleep promoters like jujube seed extract and PharmaGABA®", to help you fall asleep faster, stay asleep longer, and wake up feeling refreshed.* Emma received her B.A. in Environmental Science & Policy with a specialty in environmental communications from Duke University. In addition to penning over 1,000 mbg articles on topics from the water crisis in California to the rise of urban beekeeping, her work has appeared on Grist, Bloomberg News, Bustle, and Forbes. She’s spoken about the intersection of self-care and sustainability on podcasts and live events alongside environmental thought leaders like Marci Zaroff, Gay Browne, and Summer Rayne Oakes.